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JNJ-31020028

JNJ-31020028 is a selective and brain penetrant antagonist of neuropeptide Y Y2 receptor with pIC50 values of 8.07 and 8.22 for human and rat Y2 receptor, respectively. JNJ-31020028 can be used for the research of nervous disease[1].

Product Specifications

CAS Number

1094873-14-9

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Neuropeptide Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/JNJ-31020028.html

Concentration

10mM

Purity

98.02

Solubility

DMSO : 21.5 mg/mL (ultrasonic; warming)

Smiles

O=C(N(CC)CC)C(N1CCN(C2=CC=C(NC(C3=C(C4=CC=CN=C4)C=CC=C3)=O)C=C2F)CC1)C5=CC=CC=C5

Molecular Formula

C34H36FN5O2

Molecular Weight

565.68

Precautions

H302, H315, H319, H335

References & Citations

[1]Shoblock JR, et al. In vitro and in vivo characterization of JNJ-31020028 (N- (4-{4-[2- (diethylamino) -2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl) -2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y (2) receptor. Psychopharmacology (Berl) . 2010 Feb;208 (2) :265-77.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NPY Y2 receptor

Available Sizes

Frequently Asked Questions

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