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Histatin-3 (TFA)

Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN) . Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM[1].

Product Specifications

CAS Number

[112844-49-2]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/histatin-3.html

Purity

99.37

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

O=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(N)=O)=O)CC(O)=O)=O)CC1=CC=C(O)C=C1)=O)CC(C)C)=O)CC2=CC=C(O)C=C2)=O)CC(N)=O)=O)CO)=O)CCCNC(N)=N)=O)CC3=CC=C(O)C=C3)=O)=O)CCCNC(N)=N)=O)CC4=CNC=N4)=O)CO)=O)CC5=CNC=N5)=O)CC6=CNC=N6)=O)CCCCN)=O)CCC(O)=O)=O)CC7=CNC=N7)=O)CC8=CC=CC=C8)=O)CCCCN)=O)CCCNC(N)=N)=O)CCCCN)=O)CC9=CC=C(O)C=C9)=O)=O)CC%10=CNC=N%10)=O)CC%11=CNC=N%11)=O)CCCNC(N)=N)=O)CCCCN)=O)C)=O)CC%12=CNC=N%12)=O)CO.O=C(C(F)(F)F)O.[x]

Molecular Formula

C178H258N64O48.xC2HF3O2

Molecular Weight

4062.35 (free acid)

Precautions

H302, H315, H319, H335

References & Citations

[1]A Basak, et al. Histidine-rich human salivary peptides are inhibitors of proprotein convertases furin and PC7 but act as substrates for PC1. J Pept Res. 1997 Jun;49 (6) :596-603.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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