Damnacanthal

Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 lck autophosphorylation and phosphorylation of exogenous substrates with IC50s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against Candida albicans[1][2][3][4].

Product Specifications

CAS Number

[477-84-9]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Fungal; Src

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/damnacanthal.html

Purity

98.93

Smiles

O=CC(C(OC)=C1C2=O)=C(O)C=C1C(C3=C2C=CC=C3)=O

Molecular Formula

C16H10O5

Molecular Weight

282.25

Precautions

H302

References & Citations

[1]Faltynek CR, et al. Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity. Biochemistry. 1995 Sep 26;34 (38) :12404-10.|[2]Nualsanit T, et al. Damnacanthal, a noni component, exhibits antitumorigenic activity in human colorectal cancer cells. J Nutr Biochem. 2012 Aug;23 (8) :915-23.|[3]Aziz MY, et al. Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cells. Oncol Lett. 2014 May;7 (5) :1479-1484.|[4]Okusada K, et al. The antinociceptive and anti-inflammatory action of the CHCl3-soluble phase and its main active component, damnacanthal, isolated from the root of Morinda citrifolia. Biol Pharm Bull. 2011;34 (1) :103-7.