(Rac) -5-Hydroxymethyl Tolterodine (hydrochloride)

(Rac) -5-Hydroxymethyl Tolterodine ((Rac) -Desfesoterodine) hydrochloride, an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively) . (Rac) -5-Hydroxymethyl Tolterodine hydrochloride can be used for overactive bladder research[1].

Product Specifications

CAS Number

[250214-40-5]

Product Name Alternative

(Rac) -Desfesoterodine (hydrochloride) ; (Rac) -PNU-200577 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rac-5-hydroxymethyl-tolterodine-hydrochloride.html

Purity

97.84

Solubility

10 mM in DMSO

Smiles

[H]Cl.OC1=C(C=C(CO)C=C1)C(C2=CC=CC=C2)CCN(C(C)C)C(C)C

Molecular Formula

C22H32ClNO2

Molecular Weight

377.95

Precautions

H302, H315, H319, H335

References & Citations

[1]L Nilvebrant, et al. Antimuscarinic potency and bladder selectivity of PNU-200577, a major metabolite of tolterodine. Pharmacol Toxicol. 1997 Oct;81 (4) :169-72.|[2]B Malhotra, et al. The design and development of fesoterodine as a prodrug of 5-hydroxymethyl tolterodine (5-HMT), the active metabolite of tolterodine. Curr Med Chem. 2009;16 (33) :4481-9.|[3]Shizuo Yamada, et al. Muscarinic receptor binding of fesoterodine, 5-hydroxymethyl tolterodine, and tolterodine in rat tissues after the oral, intravenous, or intravesical administration. J Pharmacol Sci. 2019 May;140 (1) :73-78.