Eltoprazine (hydrochloride)
Eltoprazine (DU 28853) hydrochloride is a 5-HT1A/5-HT1B receptors agonist and a 5-HT2C receptor antagonist. Eltoprazine hydrochloride shows antiaggressive and anxiogenic effects[1][2].
Product Specifications
CAS Number
98206-09-8
Product Name Alternative
DU 28853 hydrochloride
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Eltoprazine-hydrochloride.html
Purity
99.25
Solubility
DMSO : ≥ 31 mg/mL|H2O : ≥ 100 mg/mL
Smiles
[H]Cl.N1(C2=C3OCCOC3=CC=C2)CCNCC1
Molecular Formula
C12H17ClN2O2
Molecular Weight
256.73
Precautions
H301, H315, H319, H335
References & Citations
[1]Sijbesma H, et al. Eltoprazine, a drug which reduces aggressive behaviour, binds selectively to 5-HT1 receptor sites in the rat brain: an autoradiographic study. Eur J Pharmacol. 1990 Feb 20;177 (1-2) :55-66.|[2]Rocha B, et al. Chronic mianserin or eltoprazine treatment in rats: effects on the elevated plus-maze test and on limbic 5-HT2C receptor levels. Eur J Pharmacol. 1994 Sep 1;262 (1-2) :125-31.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-HT1 Receptor;5-HT2 Receptor; mLAG-3; α-1 microglobulin
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