Eltoprazine (hydrochloride)

Eltoprazine (DU 28853) hydrochloride is a 5-HT1A/5-HT1B receptors agonist and a 5-HT2C receptor antagonist. Eltoprazine hydrochloride shows antiaggressive and anxiogenic effects[1][2].

Product Specifications

CAS Number

[98206-09-8]

Product Name Alternative

DU 28853 hydrochloride

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Eltoprazine-hydrochloride.html

Purity

99.25

Solubility

DMSO : ≥ 31 mg/mL|H2O : ≥ 100 mg/mL

Smiles

[H]Cl.N1(C2=C3OCCOC3=CC=C2)CCNCC1

Molecular Formula

C12H17ClN2O2

Molecular Weight

256.73

Precautions

H301, H315, H319, H335

References & Citations

[1]Sijbesma H, et al. Eltoprazine, a drug which reduces aggressive behaviour, binds selectively to 5-HT1 receptor sites in the rat brain: an autoradiographic study. Eur J Pharmacol. 1990 Feb 20;177 (1-2) :55-66.|[2]Rocha B, et al. Chronic mianserin or eltoprazine treatment in rats: effects on the elevated plus-maze test and on limbic 5-HT2C receptor levels. Eur J Pharmacol. 1994 Sep 1;262 (1-2) :125-31.