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JDTic (dihydrochloride)

Product Specifications

UNSPSC Description

JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.

Target Antigen

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein;Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/JDTic-dihydrochloride.html

Purity

98.01

Solubility

DMSO : 100 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)

Smiles

O=C([C@@H]1NCC2=C(C=CC(O)=C2)C1)N[C@@H](C(C)C)CN3C[C@H](C)[C@](C)(C4=CC=CC(O)=C4)CC3.[H]Cl.[H]Cl

Molecular Weight

538.55

References & Citations

[1]Jackson KJ, et al. Effect of the selective kappa-opioid receptor antagonist JDTic on nicotine antinociception, reward, and withdrawal in the mouse.
 Psychopharmacology (Berl). 2010 Jun;210(2):285-94.|[2]Schank JR, et al. 
The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety.
 Addict Biol. 2012 May;17(3):634-47. doi: 10.1111/j.1369-1600.2012.00455.x.|[3]Beardsley PM, et al. 
Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-10487/JDTic-dihydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-10487/JDTic-dihydrochloride-SDS-MedChemExpress.pdf

Clinical Information

Phase 1

CAS Number

785835-79-2

Available Sizes

Curated Selection

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