JDTic (dihydrochloride)

JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.

Product Specifications

CAS Number

[785835-79-2]

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/JDTic-dihydrochloride.html

Purity

98.03

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C([C@@H]1NCC2=C(C=CC(O)=C2)C1)N[C@@H](C(C)C)CN3C[C@H](C)[C@](C)(C4=CC=CC(O)=C4)CC3.[H]Cl.[H]Cl

Molecular Formula

C28H41Cl2N3O3

Molecular Weight

538.55

References & Citations

[1]Jackson KJ, et al. Effect of the selective kappa-opioid receptor antagonist JDTic on nicotine antinociception, reward, and withdrawal in the mouse. Psychopharmacology (Berl) . 2010 Jun;210 (2) :285-94.|[2]Schank JR, et al.  The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety. Addict Biol. 2012 May;17 (3) :634-47. doi: 10.1111/j.1369-1600.2012.00455.x.|[3]Beardsley PM, et al.  Effectiveness of analogs of the kappa opioid receptor antagonist (3R) -7-hydroxy-N- ((1S) -1-{[ (3R,4R) -4- (3-hydroxyphenyl) -3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl) -1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce