(E/Z) -Icerguastat (hydrochloride)

(E/Z) -Icerguastat hydrochloride ((E/Z) -Sephin1 hydrochloride) is a selective inhibitor with activity that prolongs the phosphorylation effects of eIF2α. (E/Z) -Icerguastat hydrochloride protects cells from defects in proteostasis. (E/Z) -Icerguastat hydrochloride was shown to significantly extend the survival of infected prion mice in a mouse model. (E/Z) -Icerguastat hydrochloride effectively reduces PrPSc expression and prion sequence activity in various neuronal cell lines persistently infected with different prion strains[1].