AMG319
Product Specifications
UNSPSC Description
AMG319 is a potent and selective PI3Kδ kinase inhibitor with IC50 of 18 nM.
Target Antigen
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AMG319.html
Purity
99.08
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C[C@H](NC1=C2N=CNC2=NC=N1)C3=CC4=CC=C(F)C=C4N=C3C5=NC=CC=C5
Molecular Weight
385.40
References & Citations
[1]Cushing TD, et al. Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease. J Med Chem. 2015 Jan 8;58(1):480-511.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12948/AMG319-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12948/AMG319-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
1608125-21-8
Available Sizes
Curated Selection
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