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AMG319

AMG319 is a potent and selective PI3Kδ kinase inhibitor with IC50 of 18 nM.

Product Specifications

CAS Number

[1608125-21-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AMG319.html

Purity

99.09

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@H](NC1=C2N=CNC2=NC=N1)C3=CC4=CC=C(F)C=C4N=C3C5=NC=CC=C5

Molecular Formula

C21H16FN7

Molecular Weight

385.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Cushing TD, et al. Discovery and in vivo evaluation of (S) -N- (1- (7-fluoro-2- (pyridin-2-yl) quinolin-3-yl) ethyl) -9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease. J Med Chem. 2015 Jan 8;58 (1) :480-511.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

Available Sizes

Curated Selection

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