AMG319
AMG319 is a potent and selective PI3Kδ kinase inhibitor with IC50 of 18 nM.
Product Specifications
CAS Number
[1608125-21-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AMG319.html
Purity
99.09
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C[C@H](NC1=C2N=CNC2=NC=N1)C3=CC4=CC=C(F)C=C4N=C3C5=NC=CC=C5
Molecular Formula
C21H16FN7
Molecular Weight
385.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Cushing TD, et al. Discovery and in vivo evaluation of (S) -N- (1- (7-fluoro-2- (pyridin-2-yl) quinolin-3-yl) ethyl) -9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease. J Med Chem. 2015 Jan 8;58 (1) :480-511.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Available Sizes
Curated Selection
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