SH1573
SH1573 is an orally active mIDH2 inhibitor. SH1573 has a strong and selective inhibitory effect on mIDH2 R140Q protein (IC50=4.78 nmol/L), and can effectively reduce the production of the carcinogenic metabolite 2-hydroxyglutarate (2-HG) in animal models, cell lines, serum and tumors. SH1573 can be used for the study of acute myeloid leukemia (AML) [1].
Product Specifications
CAS Number
2376068-96-9
UNSPSC
12352005
Target
Isocitrate Dehydrogenase (IDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sh1573.html
Smiles
FC(F)(F)C1=CC=CC(C2=NC(N3C[C@@](C(F)(F)F)(O)CC3)=NC(NC4=CC(C(F)(F)F)=NC=C4)=N2)=N1.CS(O)(=O)=O
Molecular Formula
C21H18F9N7O4S
Molecular Weight
635.46
References & Citations
[1]Zhiqiang Wang, et al. "Preclinical efficacy against acute myeloid leukaemia of SH1573, a novel mutant IDH2 inhibitor approved for clinical trials in China." Acta Pharmaceutica Sinica B 11.6 (2021) : 1526-1540.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Frequently Asked Questions
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