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IL-18R alpha, Mouse (HEK293, His-Fc)

Selected Variant

HY-P75846

Size: 1 Each

IL-18R alpha (interleukin-18 receptor alpha) is an interleukin receptor of the immunoglobulin superfamily. IL-18 forms a signalling complex with the IL-18 receptor α (Rα) and β (Rβ) chains at the plasma membrane, which induces multiple inflammatory cytokines[1]. IL-18R complex recruits the IL-1R- activating kinase and TNF- associated factor 6, which phosphorylates nuclear factor kβ- inducing kinase, with subsequent activation of nuclear factor kβ[2]. IL-18R alpha inhibits the production of IFN-γ stimulated with the combination of rhIL-2 and rhIL-18[3]. IL-18R alpha Protein, Mouse (HEK293, His-Fc) is a recombinant protein with a His-Fc label and is produced by HEK293 cells.

Product Specifications

Product Name Alternative

IL-18R alpha Protein, Mouse (HEK293, His-Fc), Mouse, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/il-18r-alpha-protein-mouse-hek293-his-fc.html

Molecular Formula

16182 (Gene_ID) Q61098 (K20-G326) (Accession)

Molecular Weight

Approximately 95-105 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

References & Citations

[1]Tsutsumi N, et al. The structural basis for receptor recognition of human interleukin-18. Nat Commun. 2014 Dec 15;5:5340.|[2]Watanabe M, et al. Predominant expression of 950delCAG of IL-18R alpha chain cDNA is associated with reduced IFN-gamma production and high serum IgE levels in atopic Japanese children. J Allergy Clin Immunol. 2002 Apr;109 (4) :669-75.|[3]Takei S, et al. Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis. Arthritis Res Ther. 2011 Mar 24;13 (2) :R52.|[4]Smeltz RB, et al. Regulation of interleukin (IL) -18 receptor alpha chain expression on CD4 (+) T cells during T helper (Th) 1/Th2 differentiation. Critical downregulatory role of IL-4. J Exp Med. 2001 Jul 16;194 (2) :143-53.

Shipping Conditions

Dry ice.

Scientific Category

Recombinant Proteins

Price

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