Pim-1/2 kinase inhibitor 1
Product Specifications
UNSPSC Description
Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and p27Kip1. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer[1].
Target Antigen
Pim
Type
Reference compound
Related Pathways
JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pim-1-2-kinase-inhibitor-1.html
Purity
99.90
Solubility
DMSO : 250 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(NC1=O)SC1=CC2=CC=C(OC)C=C2
Molecular Weight
235.264
References & Citations
[1]Charles D. Smith, et al. Inhibitors of PIM-1 Protein Kinases, Compositions and Methods for Treating Prostate Cancer. Patent US20110263664A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W412264/Pim-1-2-kinase-inhibitor-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W412264/Pim-1-2-kinase-inhibitor-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
6320-51-0
Available Sizes
Curated Selection
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MBS6394230-02 5x 0.1 mL
SKP1 (S-phase Kinase-associated Protein 1, Cyclin-A/CDK2-associated Protein p19, Organ of Corti Protein 2, OCP-2, Organ of Corti Protein II, OCP-II, RNA Polymerase II Elongation Factor-like Protein, SIII, Transcription Elongation Factor B, p19A, p19skp1,
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