Pim-1/2 kinase inhibitor 1
Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and p27Kip1. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer[1].
Product Specifications
CAS Number
[6320-51-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Pim
Type
Reference compound
Related Pathways
JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pim-1-2-kinase-inhibitor-1.html
Purity
99.78
Solubility
DMSO : 250 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=O)SC1=CC2=CC=C(OC)C=C2
Molecular Formula
C11H9NO3S
Molecular Weight
235.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Charles D. Smith, et al. Inhibitors of PIM-1 Protein Kinases, Compositions and Methods for Treating Prostate Cancer. Patent US20110263664A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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