TIPRL Polyclonal Antibody

TIPRL (TOR Signaling Pathway Regulator) is a Protein Coding gene. May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A) . Isoform 1 inhibits catalytic activity of the PP2A (D) core complex in vitro. The PP2A (C) : TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C: pPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AFX phosphorylated on Ser-140 (gamma-H2AFX) . May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.

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Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000