STAR3 Polyclonal Antibody

Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed: 11053434, PubMed: 15930133, PubMed: 22514632, PubMed: 28377464) . Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed: 24105263, PubMed: 28377464) . Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed: 28377464) . May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed: 12070139, PubMed: 19965586) . However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed: 28377464) . Does not activate transcriptional cholesterol sensing (PubMed: 28377464) . Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed: 21322544) .

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000