Ferruginol
Product Specifications
UNSPSC Description
Ferruginol ((+)-Ferruginol), a natural diterpenoid, is an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). Ferruginol inhibits the growth of thyroid cancer cells through the induction of mitochondrial apoptosis. Ferruginol has antitumor, cardioprotective, antioxidant, gastroprotective, and neuroprotective activities[1][2][3].
Target Antigen
Apoptosis; EBV; HSV
Type
Natural Products
Related Pathways
Anti-infection;Apoptosis
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ferruginol.html
Purity
95.0
Solubility
10 mM in DMSO
Smiles
[H][C@]1(CCC2=C3)C(C)(C)CCC[C@]1(C)C2=CC(O)=C3C(C)C
Molecular Weight
286.45
References & Citations
[1]Manabu Iwamoto, et al. Potential antitumor promoting diterpenoids from the stem bark of Thuja standishii. Planta Med. 2003 Jan;69(1):69-72.|[2]Guoqing Luo, et al. Ferruginol Diterpenoid Selectively Inhibits Human Thyroid Cancer Growth by Inducing Mitochondrial Dependent Apoptosis, Endogenous Reactive Oxygen Species (ROS) Production, Mitochondrial Membrane Potential Loss and Suppression of Mitogen-Activated Protein Kinase (MAPK) and PI3K/AKT Signaling Pathways. Med Sci Monit. 2019 Apr 21;25:2935-2942.|[3]Weili Li, et al. Ferruginol Restores SIRT1-PGC-1α-Mediated Mitochondrial Biogenesis and Fatty Acid Oxidation for the Treatment of DOX-Induced Cardiotoxicity. Front Pharmacol. 2021 Nov 24;12:773834.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N6033/Ferruginol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N6033/
Clinical Information
No Development Reported
CAS Number
514-62-5
Available Sizes
Curated Selection
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