PORIM Polyclonal Antibody

Rabbit Anti-PORIM Polyclonal Antibody

Product Specifications

Background

TMEM123 encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. TMEM123 product is proposed to function as a cell surface receptor that mediates cell death.

CAS Number

9007-83-4

Product Name Alternative

Keratinocytes-associated transmembrane protein 3; KCT-3; Pro-oncosis receptor inducing membrane injury; Transmembrane protein 123

Gene ID

114908

Accession Number

Q8N131

Reactivity

Human, Rat, Mouse

Immunogen

Synthesized peptide derived from part region of human PORIM protein

Clonality

Polyclonal

Tag

PORIM

Applications

WB, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

22kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

The antibody detects endogenous levels of PORIM protein

Observed Molecular Weight

Formulation

Liquid solution

Buffer pH

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000

Other Product Names

Keratinocytes-associated transmembrane protein 3; KCT-3; Pro-oncosis receptor inducing membrane injury; Transmembrane protein 123

Tested Applications

WB, IHC, IF, IP, ELISA

Host or Source

Rabbit

Accession Number URL

http://www.uniprot.org/uniprot/Q8N131

Isotype

Rabbit IgG

Available Sizes

Curated Selection

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