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PON1 Polyclonal Antibody

Rabbit Anti-PON1 Polyclonal Antibody

Product Specifications

Background

PON1 encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. PON1 is found in a cluster of three related paraoxonase genes on chromosome 7.

CAS Number

9007-83-4

Product Name Alternative

Serum paraoxonase/arylesterase 1; PON 1; Aromatic esterase 1; A-esterase 1; K-45; Serum aryldialkylphosphatase 1

Gene ID

5444

Accession Number

P27169

Reactivity

Human, Rat, Mouse

Immunogen

Synthesized peptide derived from part region of human PON1 protein at amino acid sequence of 51-100

Clonality

Polyclonal

Tag

PON1

Applications

IHC, IF, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

The antibody detects endogenous levels of PON1

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200

Other Product Names

Serum paraoxonase/arylesterase 1; PON 1; Aromatic esterase 1; A-esterase 1; K-45; Serum aryldialkylphosphatase 1

Tested Applications

WB, IHC, IF, IP, ELISA

Host or Source

Rabbit

Accession Number URL

http://www.uniprot.org/uniprot/P27169

Isotype

Rabbit IgG

Available Sizes

Frequently Asked Questions

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