PHLP1 Polyclonal Antibody

Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on ‘Ser-473' of AKT2 and AKT3, ‘Ser-660' of PRKCB and ‘Ser-657' of PRKCA (PubMed: 15808505, PubMed: 17386267, PubMed: 18162466) . Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity) . Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ‘Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed: 18162466) . Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed: 20513427) . Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed: 21986499) . Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed: 19079341) . Dephosphorylates RAF1 inhibiting its kinase activity (PubMed: 24530606) . May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity) . Involved in the hippocampus-dependent long-term memory formation (By similarity) . Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity) . Involved in development and function of regulatory T-cells (By similarity) .

PH domain leucine-rich repeat-containing protein phosphatase 1; Pleckstrin homology domain-containing family E member 1; PH domain-containing family E member 1; Suprachiasmatic nucleus circadian oscillatory protein; hSCOP

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000

PH domain leucine-rich repeat-containing protein phosphatase 1; Pleckstrin homology domain-containing family E member 1; PH domain-containing family E member 1; Suprachiasmatic nucleus circadian oscillatory protein; hSCOP