PARP-1 (Acetyl-K521) Polyclonal Antibody

PARP1 encodes a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly (ADP-ribosyl) ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. PARP1 (Poly (ADP-Ribose) Polymerase 1) is a Protein Coding gene. Diseases associated with PARP1 include Diphtheria and Hemorrhagic Cystitis. Among its related pathways are Necroptosis and Telomere C-strand (Lagging Strand) Synthesis.

Poly [ADP-ribose] polymerase 1; PARP-1; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD (+ ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

The antibody detects endogenous levels of PARP-1 when Acetyl occurs at Lys521 (human/rat) or Lys520 (mouse), while it doesn't react with total protein.

Poly [ADP-ribose] polymerase 1; PARP-1; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD (+ ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1