P2Y12 Polyclonal Antibody

Rabbit Anti-P2Y12 Polyclonal Antibody

Product Specifications

Background

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8) . Alternative splicing results in multiple transcript variants of this gene.

CAS Number

9007-83-4

Product Name Alternative

P2Y purinoceptor 12; P2Y12; ADP-glucose receptor; ADPG-R; P2T (AC) ; P2Y (AC) ; P2Y (cyc) ; P2Y12 platelet ADP receptor; P2Y (ADP)

Gene ID

64805

Accession Number

Q9H244

Reactivity

Human, Rat, Mouse

Immunogen

Synthesized peptide derived from part region of human P2Y12 protein at amino acid sequence of 110-190

Clonality

Polyclonal

Tag

P2Y12

Applications

WB, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

37kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

The antibody detects endogenous levels of P2Y12 protein

Observed Molecular Weight

Formulation

Liquid solution

Buffer pH

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000