Adenylyl cyclase type 2 agonist-1

Adenylyl cyclase type 2 agonist-1 (Compound 73) is a potent agonist of adenylyl cyclase type 2 (AC2) with the EC50 of 90 nM. Adenylyl cyclase type 2 agonist-1 inhibits expression of Interleukin-6, making it a potential lead compound against respiratory diseases[1].

Product Specifications

CAS Number

[2414908-52-2]

UNSPSC

12352005

Target

Adenylate Cyclase

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/adenylyl-cyclase-type-2-agonist-1.html

Purity

99.30

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

[H][C@@]1(OC2([C@]3(C(N(C([C@@]13[H])=O)C4=CC=CC=C4Cl)=O)[H])C(C5=C(C2=O)C=CC(Br)=C5)=O)C6=CC=C(C=C6)C

Molecular Formula

C27H17BrClNO5

Molecular Weight

550.78

References & Citations

[1]Guowei Xu, et al. The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation. Eur J Med Chem. 2020 Apr 1;191:112115.