Ob Polyclonal Antibody

LEP encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis, reproduction, bone formation and wound healing. Mutations inLEP and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. A mutation in LEP has also been linked to type 2 diabetes mellitus development. LEP (Leptin) is a Protein Coding gene. Diseases associated with LEP include Obesity, Morbid, Due To Leptin Deficiency and Obesity Due To Congenital Leptin Deficiency. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Transcription factor regulation in adipogenesis.

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Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200