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NRCAM Polyclonal Antibody

Rabbit Anti-NRCAM Polyclonal Antibody

Product Specifications

Background

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. NRCAM encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. NRCAM is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of NRCAM have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.

CAS Number

9007-83-4

Product Name Alternative

Neuronal cell adhesion molecule; Neuronal surface protein Bravo; NgCAM-related cell adhesion molecule; Ng-CAM-related

Gene ID

4897

Accession Number

Q92823

Reactivity

Human, Rat, Mouse

Immunogen

Synthesized peptide derived from part region of human NRCAM protein at amino acid sequence of 1050-1130

Clonality

Polyclonal

Tag

NRCAM

Applications

WB, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

143kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

The antibody detects endogenous levels of NRCAM protein

Observed Molecular Weight

143

Formulation

Liquid solution

Buffer pH

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000

Other Product Names

Neuronal cell adhesion molecule; Neuronal surface protein Bravo; NgCAM-related cell adhesion molecule; Ng-CAM-related

Tested Applications

WB, IHC, IF, IP, ELISA

Host or Source

Rabbit

Accession Number URL

http://www.uniprot.org/uniprot/Q92823

Isotype

Rabbit IgG

Available Sizes

Curated Selection

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