Apilimod (mesylate)
Apilimod (STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively[1]. Apilimod is a potent and highly selective PIKfyve inhibitor.
Product Specifications
CAS Number
[870087-36-8]
Product Name Alternative
STA 5326 (mesylate) ; LAM-002A; AIT-101 (mesylate)
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Interleukin Related; PIKfyve
Type
Reference compound
Related Pathways
Immunology/Inflammation; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/apilimod-mesylate.html
Purity
99.83
Solubility
DMSO : 12.5 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
CC1=CC=CC(/C=N/NC2=CC(N3CCOCC3)=NC(OCCC4=CC=CC=N4)=N2)=C1.CS(=O)(O)=O.CS(=O)(O)=O
Molecular Formula
C25H34N6O8S2
Molecular Weight
610.70
Precautions
H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
IL-12; IL-23; IL-4; IL-5; IL-8
Citation 01
Available Sizes
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