MEISi-1
MEISi-1 is a homeodomain inhibitor of small molecule MEIS1 protein. MEISi-1 significantly inhibited the activity of luciferase reporter genes containing MEIS binding sites (TGACAG) and induced self-renewal of mouse and human HSCS in vitro and in vivo. MEISi-1 can be used for research in blood diseases, heart regeneration and cancer[1].
Product Specifications
CAS Number
[446306-43-0]
UNSPSC
12352005
Target
HOXA
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease; Others
Assay Protocol
https://www.medchemexpress.com/meisi-1.html
Purity
98.76
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC(C)=C1C)C2=CC=C(OCC(NCC3=CC=CC=C3)=O)C=C2
Molecular Formula
C24H24N2O3
Molecular Weight
388.46
References & Citations
[1]Turan R D, et al. Development of Small Molecule MEIS Inhibitors that modulate HSC activity[J]. Scientific reports, 2020, 10 (1) : 7994.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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