Mesaconitine
Mesaconitine is the main active component of genus aconitum plants. IC50 value: Target: in vitro: In HUVECs, 30 microM mesaconitine increased the [Ca (2+) ] (i) level in the presence of extracellular CaCl (2) and NaCl, and the response was inhibited by KBR7943. Mesaconitine increased intracellular Na (+) concentration level in HUVECs. The [Ca (2+) ] (i) response by mesaconitine was inhibited by 100 microM D-tubocurarine [1]. Mesaconitine at 30 microM inhibited 3 microM phenylephrine-induced contraction in the endothelium-intact, but not endothelium-denuded, aortic rings [2]. MA promoted the alpha-MT-induced decrease in NE levels in hippocampus, medulla oblongata plus pons and spinal cord [3].
Product Specifications
CAS Number
2752-64-9
UNSPSC
12352005
Hazard Statement
H300+H330
Target
TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Mesaconitine.html
Purity
99.19
Solubility
DMSO : < 1 mg/mL (ultrasonic) |Ethanol : 4.62 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
Molecular Formula
C33H45NO11
Molecular Weight
631.71
Precautions
H300+H330
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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