Mesaconitine

Mesaconitine is the main active component of genus aconitum plants. IC50 value: Target: in vitro: In HUVECs, 30 microM mesaconitine increased the [Ca (2+) ] (i) level in the presence of extracellular CaCl (2) and NaCl, and the response was inhibited by KBR7943. Mesaconitine increased intracellular Na (+) concentration level in HUVECs. The [Ca (2+) ] (i) response by mesaconitine was inhibited by 100 microM D-tubocurarine [1]. Mesaconitine at 30 microM inhibited 3 microM phenylephrine-induced contraction in the endothelium-intact, but not endothelium-denuded, aortic rings [2]. MA promoted the alpha-MT-induced decrease in NE levels in hippocampus, medulla oblongata plus pons and spinal cord [3].

Product Specifications

CAS Number

[2752-64-9]

UNSPSC

12352005

Hazard Statement

H300+H330

Target

TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Mesaconitine.html

Purity

99.19

Solubility

DMSO : < 1 mg/mL (ultrasonic) |Ethanol : 4.62 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

Smiles

CO[C@@H]1C2([C@@](C[C@@]3(O)[C@@H]4OC(C5=CC=CC=C5)=O)([H])[C@@]4([H])[C@](OC(C)=O)([C@@H](O)[C@@H]3OC)C6C2N(C)C7)[C@@]([C@H]6OC)([H])[C@@]7(COC)[C@H](O)C1

Molecular Formula

C33H45NO11

Molecular Weight

631.71

Precautions

H300+H330

References & Citations

[1]Ogura J, et al. Mesaconitine-induced relaxation in rat aorta: role of Na+/Ca2+ exchangers in endothelial cells. Eur J Pharmacol. 2004 Jan 12;483 (2-3) :139-46.|[2]Mitamura M, et al. Mesaconitine-induced relaxation in rat aorta: involvement of Ca2+ influx and nitric-oxide synthase in the endothelium. Eur J Pharmacol. 2002 Feb 2;436 (3) :217-25.|[3]Murayama M, et al. Mechanism of analgesic action of mesaconitine. I. Relationship between analgesic effect and central monoamines or opiate receptors. Eur J Pharmacol. 1984 May 18;101 (1-2) :29-36.