Magnolol

Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 µM and 17.7 µM, respectively.

Product Specifications

CAS Number

[528-43-8]

UNSPSC

12352005

Hazard Statement

H315, H318, H335, H411

Target

Autophagy; Bacterial; PPAR; RAR/RXR

Type

Natural Products

Related Pathways

Anti-infection; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Magnolol.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(CC=C)C=C1C2=CC(CC=C)=CC=C2O

Molecular Formula

C18H18O2

Molecular Weight

266.33

Precautions

H315, H318, H335, H411

References & Citations

[1]Zhang H, et al. Molecular determinants of magnolol targeting both RXRα and PPARγ. PLoS One. 2011;6 (11) :e28253.|[2]Choi SS, et al. Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells. Life Sci. 2009 Jun 19;84 (25-26) :908-14.|[3]Zhao L, et al. Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice. Molecules. 2017 Jul 20;22 (7) . pii: E1218.