(Z) -RG-13022

(Z) -RG-13022 is a tyrosine kinase (TK) inhibitor, which inhibits preferentially the TK activity of the EGF receptor and inhibits EGF-stimulated growth of cultured cells. (Z) -RG-13022 exerts an IC50 of 11 μM for DNA synthesis in the HN5 cells, which is 3 times more potent than (E) -RG-13022 (IC50=38 μM) . (Z) -RG-13022 can be used for research of breast cancer cells[1][2].

Product Specifications

CAS Number

[149286-90-8]

Product Name Alternative

(Z) -Tyrphostin RG13022

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/z-rg-13022.html

Solubility

10 mM in DMSO

Smiles

N#C/C(C1=CN=CC=C1)=C\C2=CC(OC)=C(C=C2)OC

Molecular Formula

C16H14N2O2

Molecular Weight

266.29

References & Citations

[1]Reddy KB, et al. Inhibition of breast cancer cell growth in vitro by a tyrosine kinase inhibitor. Cancer Res. 1992 Jul 1;52 (13) :3636-41.|[2]McLeod HL, et al. In vivo pharmacology and anti-tumour evaluation of the tyrphostin tyrosine kinase inhibitor RG13022. Br J Cancer. 1996 Dec;74 (11) :1714-8.