LIGO1 Polyclonal Antibody

Rabbit Anti-LIGO1 Polyclonal Antibody

Product Specifications

Background

LINGO1 (Leucine Rich Repeat And Ig Domain Containing 1) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and RET signaling. GO annotations related to this gene include epidermal growth factor receptor binding. An important paralog of this gene is LINGO2. Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed: 14966521, PubMed: 15694321) . Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed: 15895088) . Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity) .

CAS Number

9007-83-4

Product Name Alternative

Leucine-rich repeat and immunoglobulin domain-containing protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A

Gene ID

84894

Accession Number

Q96FE5

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from part region of human LIGO1 protein at amino acid sequence of 370-450

Clonality

Polyclonal

Tag

LIGO1

Applications

WB, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

68kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

The antibody detects endogenous levels of LIGO1 protein

Observed Molecular Weight

Formulation

Liquid solution

Buffer pH

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000