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NOS1-IN-1

NOS1-IN-1 is a selective and cell-permeable nNOS inhibitor with a Ki of 120 nM. NOS1-IN-1 exhibits 2617-fold and 325-fold selectivity over eNOS (Ki=39 μM) and iNOS (Ki=325 μM), respectively[1]. NOS1-IN-1 can be used for the research of neurological disease, including cerebral palsy (CP) [2].

Product Specifications

CAS Number

357965-99-2

UNSPSC

12352211

Hazard Statement

H315-H319-H335

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nos1-in-1.html

Purity

95.0

Solubility

10 mM in DMSO|H2O : ≥ 50mg/mL

Smiles

N=C(N[N+]([O-])=O)NCCC[C@H](N)CNCCN.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

Molecular Formula

C14H24F9N7O8

Molecular Weight

589.37

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]J M Hah, et al. Reduced amide bond peptidomimetics. (4S) -N- (4-amino-5-[aminoakyl]aminopentyl) -N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase. J Med Chem. 2001 Aug 2;44 (16) :2667-70.|[2]Haitao Ji, et al. Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy. Ann Neurol. 2009 Feb;65 (2) :209-17.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NNOS

Available Sizes

Frequently Asked Questions

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