(R) -ONO-2952
(R) -ONO-2952 is a R-enantiomer of ONO-2952. ONO-2952 is a potent, selective and orally active TSPO antagonist with Kis of 0.33-9.30 nM for rat and human TSPO. ONO-2952 is more selective for TSPO than other receptors, transporters, ion channels and enzymes[1].
Product Specifications
CAS Number
2988224-39-9
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/r-ono-2952.html
Purity
99.81
Solubility
DMSO : 220 mg/mL (ultrasonic)
Smiles
CC(N1CC2(CC2)C3=C(NC4=CC=CC(F)=C43)[C@H]1C5=C(C=C(C=C5)Cl)OC)=O
Molecular Formula
C22H20ClFN2O2
Molecular Weight
398.86
References & Citations
[1]Mitsui K, et al. Anti-stress effects of ONO-2952, a novel translocator protein 18 kDa antagonist, in rats. Neuropharmacology. 2015 Dec;99:51-66.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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