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KCNN1 Polyclonal Antibody

Rabbit Anti-KCNN1 Polyclonal Antibody

Product Specifications

Background

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by KCNN1 is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN1 is a member of the KCNN family of potassium channel genes.

CAS Number

9007-83-4

Product Name Alternative

Small conductance calcium-activated potassium channel protein 1; SK1; SKCa 1; SKCa1; KCa2.1

Gene ID

3780

Accession Number

Q92952

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from part region of human KCNN1 protein at amino acid sequence of 360-440

Clonality

Polyclonal

Tag

KCNN1

Applications

WB, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

59kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

The antibody detects endogenous levels of KCNN1 protein

Product Datasheet

https://www.abbkine.com/datasheet/ABP59022.pdf

Observed Molecular Weight

59

Formulation

Liquid solution

Buffer pH

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000

Other Product Names

Small conductance calcium-activated potassium channel protein 1; SK1; SKCa 1; SKCa1; KCa2.1

Tested Applications

WB, IHC, IF, IP, ELISA

Host or Source

Rabbit

Accession Number URL

http://www.uniprot.org/uniprot/Q92952

Isotype

Rabbit IgG

Available Sizes

Curated Selection

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