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JAK2/3 (Phospho-Tyr966/939) Polyclonal Antibody

Rabbit Anti-JAK2/3 (Phospho-Tyr966/939) Polyclonal Antibody

Product Specifications

Background

JAK2 is a kinase that is misregulated or mutated in a number of myeloproliferative diseases and cancers. The mutation V617F is the most clinically relevant variant, and is seen in around half of myeloproliferative disorders. The variant is a known activating mutation, and activated JAK2 is sufficient to drive myeloproliferative disorders in mouse models. V617F, while most recurrent, is not the only mechanism by which JAK2 can be activated in patients. JAK2 is now one of the first diagnostic markers tested upon diagnosis with a myeloproliferative disorder.

CAS Number

9007-83-4

Product Name Alternative

Tyrosine-protein kinase JAK2/JAK3; Janus kinase 2/Janus kinase 3; JAK-2/JAK-3

Gene ID

1132/1124

Accession Number

O60674/P52333

Reactivity

Human:Y966/939, Mouse:Y966/935, Rat:Y966/935

Immunogen

Synthesized peptide derived from part region of human JAK2/3 (Phospho-Tyr966/939) Antibody protein at amino acid sequence of T966

Clonality

Polyclonal

Tag

JAK2/3

Applications

WB, ELISA, IHC

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

The antibody detects endogenous levels of JAK2/3 when Phospho occurs at Tyr966/939 (human) or Tyr966/935 (mouse/rat), It doesn't react with total protein.

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000

Other Product Names

Tyrosine-protein kinase JAK2/JAK3; Janus kinase 2/Janus kinase 3; JAK-2/JAK-3

Tested Applications

WB, IHC, IF, IP, ELISA

Host or Source

Rabbit

Accession Number URL

http://www.uniprot.org/uniprot/O60674

Isotype

Rabbit IgG

Available Sizes

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