Thianthrene (Standard)

Thianthrene (Standard) is the analytical standard of Thianthrene. This product is intended for research and analytical applications. Thianthrene is a potent and orally active inhibitor of Leishmania donovani pteridine reductase 1 (PTR1) . Thianthrene is a sulfur-containing tricyclic molecule distributed widely within the macro-structure of hydrocarbon fossil fuels. Thianthrene inhibits the intracellular amastigotes of Leishmania donovani (IC50 = 23 μM) . Thianthrene has a moderate anthelmintic activity. Thianthrene appears to inhibit RNA function and subsequent protein production. Thianthrene can stimulate liver regeneration in vivo[1][2].

Product Specifications

CAS Number

[92-85-3]

UNSPSC

12352005

Target

Biochemical Assay Reagents; Parasite; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Others

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/thianthrene-standard.html

Smiles

C12=CC=CC=C1SC3=C(C=CC=C3)S2

Molecular Formula

C12H8S2

Molecular Weight

216.32

References & Citations

[1]Mitchell SC, et al. Fate of thianthrene in biological systems. Xenobiotica. 2017 Aug;47 (8) :731-740. |[2]Jaspreet Kaur, et al., (2021), Thianthrene is a novel inhibitor of Leishmania donovani pteridine reductase 1 (PTR1) Journal of Molecular Biochemistry