Valanimycin
Valanimycin is an antibiotic, which inhibits Escherichia coli (BE1121) through interaction with DNA. Valanimycin exhibits cytotoxicity to mouse leukemia L1210, P388/S (doxorubicin (HY-15142A) -sensitive), and P388/ADR (doxorubicin-resistant), with IC50 of 0.79, 2.65, and 1.44 μg/mL, respectively. Valanimycin exhibits antitumor efficacy against ehrlich ascites tumors or L1210 in mice[1].
Product Specifications
CAS Number
[101961-60-8]
UNSPSC
12352211
Target
Antibiotic; Bacterial
Type
Natural Products
Related Pathways
Anti-infection
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/valanimycin.html
Smiles
CC(C)C/[N+]([O-])=N/C(C(O)=O)=C
Molecular Formula
C7H12N2O3
Molecular Weight
172.18
References & Citations
[1]Yamato M, et al., Isolation and properties of valanimycin, a new azoxy antibiotic. J Antibiot (Tokyo) . 1986 Feb;39 (2) :184-91.|[2]Yamato M, et al., Valanimycin acts on DNA in bacterial cells. J Antibiot (Tokyo) . 1987 Apr;40 (4) :558-60.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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