FANCM Polyclonal Antibody

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2) . The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. Alternative splicing results in multiple transcript variants. FANCM (Fanconi Anemia Complementation Group M) is a Protein Coding gene. Diseases associated with FANCM include Fanconi Anemia, Complementation Group A and Fancm-Related Fanconi Anemia. Among its related pathways are Fanconi anemia pathway and DNA Double-Strand Break Repair.

Fanconi anemia group M protein; Protein FACM; ATP-dependent RNA helicase FANCM Fanconi anemia-associated polypeptide of 250 kDa; FAAP250; Protein Hef ortholog

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Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000

Fanconi anemia group M protein; Protein FACM; ATP-dependent RNA helicase FANCM Fanconi anemia-associated polypeptide of 250 kDa; FAAP250; Protein Hef ortholog