DOT1L Polyclonal Antibody
Rabbit Anti-DOT1L Polyclonal Antibody
Product Specifications
Background
DOT1L encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. DOT1L (DOT1 Like Histone Lysine Methyltransferase) is a Protein Coding gene. Diseases associated with DOT1L include Diffuse Gastric Cancer and Leukemia, Acute Myeloid. Among its related pathways are Chromatin organization and Transcriptional misregulation in cancer.
Product Name Alternative
Histone-lysine N-methyltransferase, H3 lysine-79 specific; DOT1-like protein; Histone H3-K79 methyltransferase; H3-K79-HMTase; Lysine N-methyltransferase 4
Gene ID
84444
Accession Number
Q8TEK3
Reactivity
Human
Immunogen
Synthesized peptide derived from part region of human DOT1L protein at amino acid sequence of 700-780
Clonality
Polyclonal
Tag
DOT1L
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
191kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of DOT1L protein
Product Datasheet
https://www.abbkine.com/datasheet/ABP58408.pdf
Observed Molecular Weight
191
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
Histone-lysine N-methyltransferase, H3 lysine-79 specific; DOT1-like protein; Histone H3-K79 methyltransferase; H3-K79-HMTase; Lysine N-methyltransferase 4
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q8TEK3
CAS Number
9007-83-4
Isotype
Rabbit IgG
Available Sizes
Curated Selection
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