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DNA2 Polyclonal Antibody

Rabbit Anti-DNA2 Polyclonal Antibody

Product Specifications

Background

DNA2 (DNA Replication Helicase/Nuclease 2) is a Protein Coding gene. Diseases associated with DNA2 include Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 6 and Seckel Syndrome 8. Among its related pathways are DNA Double-Strand Break Repair and Telomere C-strand (Lagging Strand) Synthesis. DNA2 encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in DNA2 are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for DNA2.

CAS Number

9007-83-4

Product Name Alternative

DNA replication ATP-dependent helicase/nuclease DNA2; hDNA2; DNA replication ATP-dependent helicase-like homolog; DNA replication nuclease DNA2 ; DNA replication ATP-dependent helicase DNA2

Gene ID

1763

Accession Number

P51530

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from part region of human DNA2 protein

Clonality

Polyclonal

Tag

DNA2

Applications

WB, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

116kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

The antibody detects endogenous levels of DNA2 protein

Observed Molecular Weight

116

Formulation

Liquid solution

Buffer pH

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000

Other Product Names

DNA replication ATP-dependent helicase/nuclease DNA2; hDNA2; DNA replication ATP-dependent helicase-like homolog; DNA replication nuclease DNA2 ; DNA replication ATP-dependent helicase DNA2

Tested Applications

WB, IHC, IF, IP, ELISA

Host or Source

Rabbit

Accession Number URL

http://www.uniprot.org/uniprot/P51530

Isotype

Rabbit IgG

Available Sizes

Curated Selection

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