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DHB8 Polyclonal Antibody

Rabbit Anti-DHB8 Polyclonal Antibody

Product Specifications

Background

In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The Hydroxysteroid 17-Beta Dehydrogenase 8 encoded by HSD17B8 is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined.

CAS Number

9007-83-4

Product Name Alternative

Estradiol 17-beta-dehydrogenase 8; 17-beta-hydroxysteroid dehydrogenase 81 Publication; 17-beta-HSD 8; 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit1 Publication; KAR alpha subunit1 Publication; 3-oxoacyl-[acyl-carrier-protein] reductase Protein Ke6; Ke-6; Really interesting new gene 2 protein; Short chain dehydrogenase/reductase family 30C member 1; Testosterone 17-beta-dehydrogenase 8

Gene ID

7923

Accession Number

Q92506

Reactivity

Human, Rat, Mouse

Immunogen

Synthesized peptide derived from part region of human DHB8 protein

Clonality

Polyclonal

Tag

DHB8

Applications

WB, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

28kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

The antibody detects endogenous levels of DHB8 protein

Observed Molecular Weight

28

Formulation

Liquid solution

Buffer pH

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000

Other Product Names

Estradiol 17-beta-dehydrogenase 8; 17-beta-hydroxysteroid dehydrogenase 81 Publication; 17-beta-HSD 8; 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit1 Publication; KAR alpha subunit1 Publication; 3-oxoacyl-[acyl-carrier-protein] reductase Protein Ke6; Ke-6; Really interesting new gene 2 protein; Short chain dehydrogenase/reductase family 30C member 1; Testosterone 17-beta-dehydrogenase 8

Tested Applications

WB, IHC, IF, IP, ELISA

Host or Source

Rabbit

Accession Number URL

http://www.uniprot.org/uniprot/Q92506

Isotype

Rabbit IgG

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