DEN5A Polyclonal Antibody

Rabbit Anti-DEN5A Polyclonal Antibody

Product Specifications

Background

DENND5A (DENN Domain Containing 5A) encodes a DENN-domain-containing protein that functions as a RAB-activating guanine nucleotide exchange factor (GEF) . This protein catalyzes the conversion of GDP to GTP and thereby converts inactive GDP-bound Rab proteins into their active GTP-bound form. The encoded protein is recruited by RAB6 onto Golgi membranes and is therefore referred to as RAB6-interacting protein 1. This protein binds with RAB39 as well. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Mutations in DENND5A are associated with early infantile epileptic encephalopathy-49.

CAS Number

9007-83-4

Product Name Alternative

DENN domain-containing protein 5A; Rab6-interacting protein 1; Rab6IP1

Gene ID

23258

Accession Number

Q6IQ26

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from part region of human DEN5A protein at amino acid sequence of 650-730

Clonality

Polyclonal

Tag

DEN5A

Applications

WB, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

141kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

The antibody detects endogenous levels of DEN5A protein

Observed Molecular Weight

141

Formulation

Liquid solution

Buffer pH

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000