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CUL5 Polyclonal Antibody

Rabbit Anti-CUL5 Polyclonal Antibody

Product Specifications

Background

Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS (SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

Product Name Alternative

Cullin-5; CUL-5; Vasopressin-activated calcium-mobilizing receptor 1; VACM-1

Gene ID

8065

Accession Number

Q93034

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from part region of human CUL5 protein at amino acid sequence of 560-640

Clonality

Polyclonal

Tag

CUL5

Applications

WB, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

85kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

The antibody detects endogenous levels of CUL5 protein

Product Datasheet

https://www.abbkine.com/datasheet/ABP58300.pdf

Observed Molecular Weight

85

Formulation

Liquid solution

Buffer pH

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000

Other Product Names

Cullin-5; CUL-5; Vasopressin-activated calcium-mobilizing receptor 1; VACM-1

Tested Applications

WB, IHC, IF, IP, ELISA

Host or Source

Rabbit

Accession Number URL

http://www.uniprot.org/uniprot/Q93034

CAS Number

9007-83-4

Isotype

Rabbit IgG

Available Sizes

Curated Selection

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