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Mioflazine di (hydrochloride)

Mioflazine dihydrochloride is a nucleoside transport inhibitor with sleep-improving activity. Mioflazine dihydrochloride significantly improves cardiac survival after global cardiac ischemia. Mioflazine dihydrochloride reduces the mitochondrial calcium content in guinea-pig. Mioflazine dihydrochloride does not exhibit inotropic effects during induction and nursing[1][2][3][4].

Product Specifications

CAS Number

83898-67-3

UNSPSC

12352005

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/mioflazine-di-hydrochloride.html

Smiles

O=C(C1N(CCCC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)CCN(C1)CC(NC4=C(Cl)C=CC=C4Cl)=O)N.Cl.Cl

Molecular Formula

C29H32Cl4F2N4O2

Molecular Weight

648.40

References & Citations

[1]Wauquier A, et al. Sleep improvement in dogs after oral administration of mioflazine, a nucleoside transport inhibitor. Psychopharmacology (Berl) . 1987;91 (4) :434-9.|[2]Pirovano IM, et al. Inhibition of nucleoside uptake in human erythrocytes by a new series of compounds related to lidoflazine and mioflazine. Eur J Pharmacol. 1990 Dec 15;189 (6) :419-22.|[3]Mioflazine, a potentially protective drug against ischaemic damage: a study in dogs|[4]J G Hugtenburg, et al. The influence of nifedipine and mioflazine on mitochondrial calcium overload in normoxic and ischaemic guinea-pig hearts. Eur J Pharmacol. 1990 Mar 13;178 (1) :71-8.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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