TCID

TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC50 of 0.6 μM[1]. TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons[2].

Product Specifications

CAS Number

30675-13-9

Product Name Alternative

4,5,6,7-Tetrachloroindan-1,3-dione

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Deubiquitinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tcid.html

Purity

99.78

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

O=C1CC(C2=C1C(Cl)=C(Cl)C(Cl)=C2Cl)=O

Molecular Formula

C9H2Cl4O2

Molecular Weight

283.92

Precautions

H302, H312, H332

References & Citations

[1]Liu Y, et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cellline. Chem Biol. 2003 Sep;10 (9) :837-46.|[2]de Juan-Sanz J, et al. Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS One. 2013;8 (3) :e58863.