YD1130
YD1130 is a PRMT4 inhibitor (0.5 nM, 75% inhibition rate), and its inhibitory potency against other PRMTs is not significant (PRMT5 IC50> 1 μM, PRMT1/3/6/7/8 IC50 > 10 μM) .[1].
Product Specifications
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yd1130.html
Smiles
NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](CSCCNCC4=CC(Br)=CC=C4)[C@@H](O)[C@H]3O
Molecular Formula
C19H23BrN6O3S
Molecular Weight
495.39
References & Citations
[1]Deng Y, et al. An Adenosine Analogue Library Reveals Insights into Active Sites of Protein Arginine Methyltransferases and Enables the Discovery of a Selective PRMT4 Inhibitor. J Med Chem. 2024 Oct 24;67 (20) :18053-18069.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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