PSB-KK1445
PSB-KK1445 is a potent and selective GPR18 agonist with EC50s of 45.4 nM and 124 nM for human and mouse GPR18, respectively. PSB-KK1445 displays >200-fold selectivity versus both CB receptor subtypes, GPR55, and GPR183[1].
Product Specifications
CAS Number
885896-54-8
UNSPSC
12352005
Target
Cannabinoid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/psb-kk1445.html
Purity
99.47
Smiles
CN1C2=C(C(N(C1=O)C)=O)N(C(NCCC3=CNC4=C3C=CC=C4)=N2)CC5=CC=C(C=C5)F
Molecular Formula
C24H23FN6O2
Molecular Weight
446.48
References & Citations
[1]Andhika B Mahardhika, et al. Potent, Selective Agonists for the Cannabinoid-like Orphan G Protein-Coupled Receptor GPR18: A Promising Drug Target for Cancer and Immunity. J Med Chem. 2024 Jun 27;67 (12) :9896-9926.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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